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An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a is ofIgG1 isotype, b shows a ratio of IC50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IG-II to IGF-IR of 1:3 to 3:1, c inhibits for at least 80% at a concentration of 5 nM IGF-IR phospohrylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum when compared to such an assay without said antibody, and d shows no IGF-IR stimulating activity measured as IGF-IR phophorylation at a concentration of 10 M in a cellular phosphorylation assay using 3T3 providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0,5% heat inactivated fetal calf serum when compared to such an assay without said antibody has improved properties in antitumor therapy.
一种已经提高了抗肿瘤治疗的特性的抗体,所述抗体结合IGF-IR并且抑制IGF-I和IGF-II与IGF-IR结合,其特征在于所述抗体a是IgG1同种型,b显示其对IGF-I与IGF-IR结合的抑制的IC 50 值与其对IGF-II与IGF-IR结合的抑制的IC 50 值的比率为1∶3-3∶1,c当与没有所述抗体的这种测定比较时,其在5nM的浓度上,在包含0.5%的热灭活胎牛血清的培养基中,使用3T3细胞的细胞磷酸化测定中,抑制至少80%的IGF-IR磷酸化,所述3T3细胞提供400,000-600,000分子IGF-IR/细胞,和d当与没有所述抗体的这种测定相比,在包含0.5%的热灭活胎牛血清的培养基中,使用3T3的细胞磷酸化测定中,其在10μM的浓度上没有显示作为IGF-IR磷酸化所测量的IGF-IR刺激活性,所述3T3提供400,000-600,000分子IGF-IR/细胞。
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Results The SP-IR and CGRP-IR neurons could not be found in the above-mentioned ganglial plexus.But SP-IR fibers distributed sparsely,CGRP-IR fibers were more densely than SP-IR fibers,especially A-PGP.The population of VIP-IR neurons and fibers were most dense and interweaved ganglial plexus.
结果 在上述三个神经节丛内,未发现SP及CGRP免疫反应阳性神经元,但可见少量SP免疫反应阳性神经纤维分布,CGRP免疫反应阳性神经纤维数量较SP阳性纤维密集,尤其在A-PGP更为明显;VIP免疫反应阳性神经元和神经纤维分布最为密集,交织成神经节丛。
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High-level participation in the company's IR, IR set up organizations, IR three aspects of the quality of personnel, in 2007 listed companies scored an average of 55.49,60.27 and 24.34 respectively, the management level, the average index score of 49.98, indicating China's listed companies in the quality of personnel there IR Less obvious.
高级别公司的红外参与,组织成立了红外,红外三方面的人员素质,2007年上市公司中,取得了55.49,60.27和24.34,平均分别管理水平,平均指数的49.98分,显示中国上市公司在人员素质有红外不太明显。
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ir : Iran:伊朗
iq : Iraq , 伊拉克 | ir : Iran , 伊朗 | is : Iceland , 冰岛
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ir : Iran:伊朗 亚洲
IQ Iraq伊拉克 亚洲 | IR Iran伊朗 亚洲 | VA Vatican City梵蒂冈 欧洲
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ir : Iran:伊朗(域名)
II IpswitchInc "网际转换器"公司(美国,出品网络设备、邮件服务器等) | IR Iran 伊朗(域名) | IQ Iraq 伊拉克(域名)
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ir : Iran:伊朗 DXB 迪拜 中东
9 PF FRENCH POLYNESIA 法属玻利尼西亚 AKL 奥克兰 南太 | 10 IR IRAN 伊朗 DXB 迪拜 中东 | 12 JO JORDAN 约旦 DXB 迪拜 中东
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.ir:伊朗
从伊马高美尼 (IKA)起飞的机票 - 快速、全面航班搜寻从伊朗 (IR)伊马高美尼 (IKA)起飞的航班从伊马高美尼 (IKA)机场起飞的航班?从 伊马高美尼 (IKA) 起飞的廉价航班 - 快速、全面航班搜寻 - © Skyscanner Ltd 2002–2009
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