Giengen an der Brenz
- Giengen an der Brenz的基本解释
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[地名] [德国] 布伦茨河畔京根
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City / 城市
[3852]
Alene · Zwijndrecht · Zuchwil · Zonhoven · Zoetermeer · Zittau · Zell am See · Zelandia · Zaventem · Zaragoza
- 更多 网络例句 与Giengen an der Brenz相关的网络例句 [注:此内容来源于网络,仅供参考]
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From the calculations, it can be found that the van der Waals interactions, the hydrophobic interactions, as well as the H-bonding interactions are crucial for the ligand binding. The 4-phenylamino group can produce strong van der Waals adn hydrophobic interactions with the nonpolar side chains of the residues deep in the binding cleft. The R^1 and R^2 substituents on the bicyclic chromophore can also produce strong van der Waals and hydrophobic interactions with the residues located at the exterior part of the binding pocket. Moreover, the two N atoms of the quinazoline can form H-bonds with EGFR, which will produce significant contribution to biological activities. The calculated nonbonded interactions between anilinoquinazolines and EGFR, as well as the information obtained from the predicted complexes, can interpret the structure-activities of the inhibitors well, which can afford us important information for structure-based drug design.
从模拟结果得到的抑制剂和靶酶之间的相互作用模式表明范德华相互作用、疏水相互作用以及氢键相互作用对抑制剂的活性都有重要的影响,抑制剂的苯胺部分位于活性口袋的底部,能够与受体残基的非极性侧链产生很强的范德华和疏水相互作用,抑制剂双环上的取代基团也能和活性口袋外部的部分残基形成一定的范德华和疏水性相互作用,而抑制剂喹唑啉环上的氮原子能和周围的残基形成较强的氢键相互作用,对抑制剂的活性有较大的影响,计算得到抑制剂和靶酶之间的非键相互作用能以及抑制剂和靶酶之间的相互作用信息能够很好地解释抑制剂活性和结构的关系,为全新抑制剂的设计提供了重要的结构信息。
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The kenosis, or the exinanition, of His Divine attributes was, therefore, a free act of Christ, according to Brenz; it was the connatural consequence of the Incarnation, according to Chemnitz.
该kenosis ,或荒废,他的神的属性,因此,一个自由的行为基督,根据北京时间;,这是固有的后果,道成肉身,根据开姆尼茨。
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This passion has led him to conduct the Japan premieres of Philip Glass's Peace Symphony, Busoni's Piano Concerto and Doktor Faust, Zemlinsky's Der Geburtstag der Infantin, Sch?0?2nberg's Notturno, Takemitsu's Spectral Canticle, as well as works by Messian, Andriessen, Górecki, Ligeti, Lutoslawski, Berio, Dutilleux, Xenakis, Birtwistle and Matthews; each composer praised him for his "impeccable understanding" of their works.
这样的激情促使他指挥了菲利浦·格拉斯的《和平交响曲》、布索尼的钢琴协奏曲和《浮士德博士》,策姆林斯基的《公主的生日》、勋伯格的《小夜曲》、武满徹的《幻觉的赞美诗》,以及由梅西安、安德里森、戈雷茨基、利盖蒂卢托斯瓦夫斯基、贝里奥、迪蒂耶、克塞纳基斯、伯特威斯尔以及马修斯;每位作曲家都把他评价为对他们在作品有着'无可挑剔的理解'。
- 更多网络解释 与Giengen an der Brenz相关的网络解释 [注:此内容来源于网络,仅供参考]
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Lorette:劳蕾特
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