- 拼写相近词组、短语
- gala party
- galact-
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Recently, it is proved that SP is also involved in pain modulation, acupuncture analgesia and immunoin- hibition. However, the role of CGRP in them is unclear Therefore, the dy- namic changes of CGRP-, SP-like immunoreactivity and expression ofα- CGRP,β-CGRP mRNAs in dorsal root ganglion and spinal cord in the arthritic rats were observed by using immunohistochemistry and in situ hybridization techniques combined with behavioral tests, respectively. Subsequently, the effects of this peoptide on the develoment of polyarthritis were investigated by intrthecal injections of CGRP and its antagonist in the rats. In addtion, GAL is a novel neuropeptide which coexists with CGRP and SP, but it may play a different role in the primary sensory system. Thus, we also observed the changes of GAL and GAL mRNA in DRG neurons and the spinal cord. The results were as follows
为此本文拟在大鼠佐剂性关节炎模型上，结合行为学测定、用免疫组织化学、原位核酸分子杂交技术观察脊髓背角及DRG中CGRP、SP、α-CGRP mRNA、β-CGRPmRNA的动态变化及电针的影响，此外，用鞘内和外周注射CGRP的工具药探讨了CGRP在佐剂性关节炎发生发展中的可能作用；甘丙肽（Galanin，GAL）也是新近发现的一个神经肽，并与CGRP和SP共存于DRG及初级传入末梢中，在神经损伤模型中脊髓CGRP、SP减少，GAL则明显增加，显示GAL与CGRP和SP的作用可能不同，因此在佐剂性关节炎模型上也同时观察了GAL和GAL mRNA的变化，实验结果如下
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Based on the above-mentioned, two kinds of target glycoclusters with different glycoterminus, flexible linkers and different scaffolds were designed, disaccharide glycocluster (including TM1-TM7) and trisaccharide glycocluster (TM8-TM9) respectively, with the purpose of obtaining glycoclusters with high binding affinity to anti-Gal antibody and thus better inhibiting the HAR.
基于上述，针对HAR产生的机制，以人体中天然存在的anti-α-Gal抗体及B细胞表面的相应受体为靶点，以α-Gal抗原末端的二糖Galα1→3Gal和三糖Galα1→3Galβ1-4GluNAc片段为糖基部分，采用柔性的连接臂（氨基保护的2-乙醇胺和3-巯基丙酸）和刚性的芳香骨架及柔性的脂肪链骨架，设计了两类结构新颖的糖簇分子：即氧苷和硫苷键连接的二糖糖簇TM1-TM7）和三糖糖簇（TM8-TM9），目的在于寻找与anti-Gal抗体及B细胞相应受体有较高结合力的糖簇分子，以便有效地抑制HAR反应的发生。
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It was possible that these different expressions of MHC class Ⅱ molecules and Gal-α-Gal epitopes would be one of the reasons leading to the failure in interfamily pregnancy.
标 签 金黄地鼠小鼠科间妊娠 MHCⅡ Gal-α-Gal抗原决定簇 golden hamster mouse interfamily pregnancy MHCⅡ Gal-α-Gal epitope
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Human galactose-6-sulphate sulphatase,Gal-6S ELISA Kit：人半乳糖6硫酸酯酶(Gal-6
Human pyruvate kinase,PK ELISA Kit 人丙酮酸激酶(... | Human galactose-6-sulphate sulphatase,Gal-6S ELISA Kit 人半乳糖6硫酸酯酶(Gal-6S)ELISA Kit | Human iduronate sulfatase,IDS ELISA Kit 人艾杜糖硫酸酯酶...
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Human galactose-6-sulphate sulphatase,Gal-6S ELISA Kit：人半乳糖6硫酸酯酶(Gal-6S)ELISA试剂盒
人核糖核酸酶(RNASE)ELISA试剂盒 Human Ribonucleas... | 人多巴胺脱羧酶(DDC)ELISA试剂盒 Human dopamine decarbo... | 人半乳糖6硫酸酯酶(Gal-6S)ELISA试剂盒 Human galactose-6-sulphate sulphatase,Gal-6S ELISA Kit
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Gal-6S, Mouse galactose-6-sulphate sulphatase,Gal-6S ELISA Kit：小鼠半乳糖6硫酸酯酶
人半乳糖6硫酸酯酶,Gal-6S, Human galactose-6-sulphate sulphatase,Gal... | 小鼠半乳糖6硫酸酯酶,Gal-6S, Mouse galactose-6-sulphate sulphatase,Gal-6S ELISA Kit | 人苯丙氨酸,LPA, Human L-phenylalanine,LPA E...