Charles IV
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S first hot springs, hunting by Charles IV discovered The Charles IV Spring, has stopped the flow of the House of Lords castle Hot Springs, in the spring next to the Charles IV, the goddess of hot springs, hot springs, etc. Hard Rock are in there, it can be said of all the famous hot springs remains卡罗维瓦里almost all gathered here by then.
卡罗维瓦里的第一处温泉、由查理士四世狩猎时发现的The Charles IV Spring、已经停止流动的上议院城堡温泉、在查理士四世温泉旁的女神温泉、硬石温泉等等都在该处,可以说卡罗维瓦里所有有名的温泉遗迹几乎都聚集在此了。
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Methods: FOLFOX4 regimen was oxaliplation 100mg/m~2, 2 hours iv drop on d1 , calcium foliate 200mg iv drop 2 hours on d1.d2, followed by fluorouracil 400mg/m~2 iv on d1.d2 and fluorouracil 600 mg/m~2 iv drop d1.d2,and repeated every 2 week.
采用FOLFOX4方案,即L-OHP100mg/m2,静脉滴入2h,d1;CF200mg,静脉滴入2h,d1.d2;注射后立即静脉推注氟尿嘧啶(5-Fu)400mg/m2,d1.d2;5-Fu600mg/m2持续静滴d1.d2;每2周重复,28天为1周期。2个周期化疗后进行疗效评价。
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Theurinary IL-6 level positively correlated with density of glomerular matrix membrane, global sclerosis, fiber or fibrocellular crescents and interstitial fibrosis (p. 05). According to the degree of density of glomerular matrix membrane and interstitial fibrosis, urinary Col-IV level had better correlation than urinary TGF-betal and IL-6 levels.In IgAN, Col-IV showed increased expression in diseased renal tissue whereas the site of expression of TGF-betal was mainly localized within the cytoplasm of tubular epithelial cells. Interstial expressionwas also present but glomerular TGF-betal expression was found only in patients with heavy mesangial proliferation. There was a significant correlation between glomerular positivity for Col-IV and severity of histological damage. There was also a significant correlation between positivity for TGF-betal and Col-IV in the tubular epithelial and interstitial lesions. In contrast, there was no ralationship between glomerular positivity for TGF-betal and severity of histological damage.The urinary TGF-betal level paralleled tubular TGF-betal expression.
结果 ①IgAN患者尿TGF-β1、IL-6、Col-Ⅳ水平较健康人明显增高(P<0.01),该变化与血中的浓度无关(P>0.05);②尿TGF-β1水平与小管间质TGF-β1阳性表达呈正相关(P=0.000),而与小球TGF-β1阳性表达无关(P>0.05),尿Col-Ⅳ水平与小球和小管间质Col-Ⅳ阳性表达均呈良好的相关性(P<0.01),还与小管间质TGF-β1阳性表达呈正相关(P<0.05):③小球Col-Ⅳ阳性表达与肾组织慢性病变密切相关(P<0.05),小管间质Col-Ⅳ和TGF-β1阳性表达均与肾小管间质病变呈良好的相关性(P<0.01),而小球TGF-β1阳性表达与肾组织损伤无关(P>0.05);④尿TGF-β1、Col-Ⅳ水平与肾小球基质基底膜面密度、小管间质病变呈正相关(P<0.01),与小球内细胞数呈负相关(P<0.05),该结果与其在组织中的表达一致;尿IL-6水平浙江大学硕士学位论文尿TGF一B一、IL一6和Col一IV在IgA肾病中的应用价值与基质基底膜面密度、球性硬化、纤维或细胞纤维新月体所占肾小球百分数及小管间质病变均有显著的相关性(F.05);在轻度肾病理损伤时,尿'l'G卜pl、I卜6、Col一IV水平即升高,而尿Col一W在反映细胞外基质积聚和间质纤维化程度上比尿TGF一pl和IL一6有更好的相关性。
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Charles IV,Emperor:查理四世皇帝
Chapman,Robert Cleaver 戚卜门(卓曼),263 | Charles IV,Emperor 查理四世皇帝,146 | Charles V,Emperor 查理五世皇帝,170